Abstract
The relationship between GH1 IGF-I, GHBP and IGFBP-3 level in normals and adolescents with IDDM have not been adequately defined. We have measured IGF-I and IGFBP-3(RIA)), GHBP(LIFA) in samples from 89 normal (40F, 49M) and 94 IDDM (54F, 40M) subjects matched for puberty stage (G1-5, B1-5). Coincident mean overnight GH data (15 minute sampling, 20.00h-08.00h, IRMA) were available from 33 normal and 30 IDDM subjects. Maximal IGF-I levels were noted at G4, B3 in normals and G5, B3 in IDDM. Levels were significantly lower in diabetes at 65 (p<0.05) and B4 (P<0.002). In normals and diabetics maximal IGFBP-3 were noted at B3 (6.7±1,2 mg/ml and 5.3±1.0 mg/ml respectively) and 64 (6.4±0.7 mg/ml and 4.6±1.0 mg/ml) with reduced levels in the diabetics at B2, B4 and G2-5. GHBP did not change significantly during puberty in normals or IDDM but the latter had lower levels at B3-41 G1-3. GH concentrations were greatest at B2-3 and G4-5 in nonals and were greater in diabetics at all stages. In normals there was a correlation after log transfonation between GH and GHBP (r=−0.59, p<0.001) and IGF-I and IGFBP-3 (r=0.51, p<0.001). In IDDM the relationship between IGF-I and IBFBP-3 (r=0.55, p<0.001) was retained, there was no correlation between GH and GHBP1 however a weak correlation between GH and IGF-I (r=0.38, p<0.04) was evident. During puberty GH is increased, yet IGF-I, IGFBP-3 and GHBP are reduced in IDDM. The normal negative correlation between GH and GHBP is lost. The relationship between IGF-I and IGFBP-3 is similar in both groups of subjects.
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Dunqer, D., Holly, J., Cheetha, T. et al. THE RELATIONSHIP BETWEEN GH, IGF-1, IGFBP-3 AND GH BINDING PROTEIN (GHBP) IN NORMAL AND ADOLESCENTS WITH INSULIN-DEPENDENT DIABETES MELUTUS (IDDM). Pediatr Res 33 (Suppl 5), S75 (1993). https://doi.org/10.1203/00006450-199305001-00431
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DOI: https://doi.org/10.1203/00006450-199305001-00431