Abstract
Patients with GH deficiency or idiopathic short stature (ISS) demonstrate improved growth rate and predicted adult height with GH therapy prior to puberty. However, some studies have suggested that there is an increased rale of pubertal development and skeletal maturation with GH therapy during puberty. We studied patients with GHD and ISS enrolled in multicenter trials in which rhGH therapy (0.3 mg/kg weekly) was initiated before puberty. Bone ages (BA) were determined centrally by the FELS method. The table below shows the mean and (n) for change in BA, change in height SDS adjusted for bone age (HtSDSBA), and change in Bayley-Pinneau (BP) predicted adult height, each divided by change in chronological age (CA). Patients were grouped according to pre-pubertal or pubertal bone ages. Bone ages taken at least 1 yr apart were used.
CONCLUSIONS: The yearly change in height SDSBA was positive in all groups. All group improved BP predicted height with the exception of pubertal male ISS patients, suggesting the importance of early treatment for these patients.
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Hintz, R., August, G., Attie, K. et al. SKELETAL MATURATION AND GROWTH DURING PUBERTY IN PATIKNTS WITH GROWTH HORMONE (GH) DEFICIENCY OR IDIOPATIHC SHORT STATURE TREATED WITH GH. Pediatr Res 33 (Suppl 5), S65 (1993). https://doi.org/10.1203/00006450-199305001-00370
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DOI: https://doi.org/10.1203/00006450-199305001-00370