Abstract
We studied plasma OH levels during 24-h GH profiles and after arginine stimulation (ATT) and measured day and night urinary GH secretion (U-GH) and IGF-I and -II levels in 40 prepubertel children (25 boys/15 girls) with short stature after IUGR (defined as a birthlength < P3). Wean (range) age was 7.5 (3-11) years. Mean (SD) height SDS (H-SDS) and height velocity SDS (HV-SDS) was −2.95 (0.62) and −1.08 (0.97). respectively. GH profiles were analysed with PULSAR.
ATT: Max. GH response during ATT (peek ATT) was 22.3 mU/l (12.1) children had a max. GH-response less than 20 mU/l. IGF-I and -II: Plasma IGF-I SDSCA was −0.88 (1.39) and IGF-II SDSCA was −0.64 (1.48). U-GH: U-GH excretion was 10.42 (4.91) μU/24h. divided in 5.90 (3.16) μU/daytime and 4.38 (2.62) μU/nighttime. Correlations: The 24-h GH profile characteristics such as mean GH, number of peaks > 20 mU/l. AUCb, and the sum of the amplitudes correlated significantly with the peak ATT (r-values:0.31-0.35: P<0.05) and the U-GH excretion (r-valuas: 0.33-0.67;P between <0.001 and <0.05). No correlations were found with the growth parameters (H-SDS, HV and HV-SDS) or the IGF-I and -II levels. However penk ATT correlated significantly with IGF-I SDSCA (r=0.43;P<0.01). The growth parameters were not correlatod with either IGF-levels, U-GH excretion or peak ATT.
CONCLUSIONS: GH secretion in children with short stature after IUGR lo heterogeneous, but many children show low or subnormal spontaneous GH secretion, while IGF-I as well as IGF-II levels tends to be in the low-normal range.
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Da Waal, W., Hokken-Koelega, A., Stijnen, T. et al. 24-HOURS PLASMA GROWTH HORMONE (GH) PROFILES, URINARY GH-EXCERTION AND PLASMA IGF-I AND II LEVELS IN PREPUBERTAL CHILDREN WITH SHORT STATURE AFTER INTRAUTERINE GROWTH RETARDATION (IUGR). Pediatr Res 33 (Suppl 5), S62 (1993). https://doi.org/10.1203/00006450-199305001-00351
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DOI: https://doi.org/10.1203/00006450-199305001-00351