Abstract
Little is known about the mechanisms of the effect og exogeneous glucocorticosteroids. The aim of the present study was to assesss whether low doses of oral prednisolone affect serum levels of ICF-1, ICF binding protein-3, the carboxyterminal propeptide of type III procollagen (PICP) and the aminoterminal propeptide of type III procollarjen (PIIINP). A group of 10 children with asthma aged 7-11 years was studied. The design was a randomised double-blind cross-over trial with run-in, wash-out and two active periods of 15 days. During run-in and wash-out placebo was given. During active treatment periods 2.5 or 5 mg prednisolono were given per day. Blood samplus were taken at the end of the periods. ICF-1 and 1GFBP-3 were not statistically significantly influenced by the treatments. PICP (ng/ml) was 345 (run-in;, 319 (2.5 mg) and 275 (5 mg); Pages test :P<0.05. PIIINP (ng/ml) was 7.84 (run-in), 5.96 (2.3 my) and 4.69 (5.0 mg); Pages tetst :P<0.01. Oral prediusolone Causes a dose related reduction of procollagen I and III indicating a suppression of collagen synthesis. Thus may explain the growth retarding effect of systemic glucocorticosteroids.
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Wolthers, O., Juul, A., Hansen, H. et al. IGF-I, IGF BINDING PROTEIN-3 AND PROCOLLAGEN I AND III IN ASTHMATIC CHILDREN TREATED WITH LOW DOSES OF PREDNISOLONE. Pediatr Res 33 (Suppl 5), S61 (1993). https://doi.org/10.1203/00006450-199305001-00348
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DOI: https://doi.org/10.1203/00006450-199305001-00348