Abstract
It has recently been shown that sweat secretion rate (SSR),measured by pilocarpin iontophoresis, is reduced in patients with GH insufficiency and increases during GH treatment. Thus, GH seems to exert a metabolic influence on sweat gland function which may be mediated through IGF-l. We measured SSR in 7 untreated patients with Laron's syndrome. patient 1 was then treated with IGF-1 for 22 weeks. The results were compared to SSR in 254 puberty- and sex matched healthy children.
Results: SSR was significantly reduced in Laron's syndrome to subnormal values in 4 and very low values in 3 patients (p<0.00001), independently on the presence or absence of detectable serum IGF-1. Treatment with IGF-1 did not increase SSR.
Table: Sex /Age Tanner SSR mg/30min (normal range)
The results support the hypothesis that the effect of GH on sweat gland function is mediated through IGF-1, probably by a paracrine mechanism. Tho effect of long-term IGF-1 treatment on sweating in Laron's syndrome remains to be evaluated.
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Main, K., Price, D., Savage, M. et al. DECREASED SWEATING IN LARON'S DWARFISM. Pediatr Res 33 (Suppl 5), S39 (1993). https://doi.org/10.1203/00006450-199305001-00216
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DOI: https://doi.org/10.1203/00006450-199305001-00216