EVIDENCES OF OVARIAN HYPERFUNCTION IN ADDLESCENT GIRLS WITH INSULIN DEPENDENT DIABETES MELLITUS (IDDM) AND MENSTRUAL DISORDERS

Abstract

Diabetic women present an elevated incidence of mestrual disorders often associated with partial gonadotropic insufficiency with reduced LH, E2 and ovarian androgen production. Among our adolescent IDDM population 8 over 36 postmenarcheal girls (22%) complained of oligo- or amenorrhea and 4 of hirsutism also. To verify therir pituitary and ovarian functions we assessed the gonadotropine and ovarian steroid response to the administration of 500 ng s.c. of GnRHa Leuprolide acetate in 7 patients with IDDM (age 17.8±1.7 yrs) and 12 age-matched normal girls. Basal and stimulated LH, FSH, E2, DEAS, 1 and basal 17OHP and 04-A levels were similar in the two groups, regardless of elevated baseline androgens levels in few girls. 24hr-stimulated 17OHP levels were significantly higher in patients than in controls (7.8±2.2 vs. 2.8±0.3 nMol/L, P 0.0001). D4-A responses were also higher than in control although the difference was not statistically significant (9.8±1.4 vs. 6.1±0.7 nMol/L n.s.). This behaviour was similar to that of a previously studied group of 35 adolescents with hirsuitism and ovarian hyperfunction (17OHP 7.0±0.4 nMol/L, D4-A 11.2±0.9 nMol/L). These data demonstrate the presence of a high incidence of ovarian hyperfunction in adolescent diabetic girls which can underline the menstrual disorders. We need a follow-up of these patients to clarify whether they will develop a clear hyperandrogenism, as suggested by our results, or a partial gonadotropin insufficiency as other observed in older diabetic patients.

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Virdis, R., Vanelli, M., Ibanez, L. et al. EVIDENCES OF OVARIAN HYPERFUNCTION IN ADDLESCENT GIRLS WITH INSULIN DEPENDENT DIABETES MELLITUS (IDDM) AND MENSTRUAL DISORDERS. Pediatr Res 33, S20 (1993). https://doi.org/10.1203/00006450-199305001-00102

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