Abstract
Hypoglycemia (HG) is associated with increased cerebral blood flow. We have shown dilation of PA in the newborn pigs during HG. To determine if this is caused by the cerebral vasodilator adenosine (ADO), we studied the effects of 8-sulphophenyl-theophylline (8-SPT), an ADO receptor antagonist on HG-induced dilation of PA. A cranial window was implanted over the right parietal cortex of newborn pigs for observation of a selected PA (50-100 μm) by videomicroscopy at 20 min intervals. 2 μm changes in vessel diameter could be resolved. HG was induced by insulin in 9 matched control and 9 8-SPT piglets. In the latter group, the window was superfused (50 μl/min) with 10−5 M 8-SPT prior to manifest HG (blood glucose < 1.4 mmol/l).
RESULTS: PA diameter (mean ± SEM; μm) are shown in table: * p<0.05 vs normoglycemia (NG); ** p<0.05 vs corresponding HG in controls.
CONCLUSION: The attenuation of PA dilations by 8-SPT indicates that adenosine participates in the mediation of HG-related brain hyperemia.
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Ruth, V., Gidday, J., Gonzales, E. et al. EFFECT OF ADENOSINE RECEPTOR BLOCKADE ON HYPOGLYCEMIA-INDUCED DILATIONS OF PIAL ARTERIOLES (PA) IN PIGLETS. Pediatr Res 32, 631 (1992). https://doi.org/10.1203/00006450-199211000-00156
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DOI: https://doi.org/10.1203/00006450-199211000-00156