Abstract
The effect Ca-blockade (Ca-B) (continuous infusion of nimodipine, 15 microg./kg/min) on mean arterial blood pressure (MABP) and cerebral blood flow (CBF) after hypoxemia (HO, 10% O2) was studied in 29 newborn piglets with the microsphere method. CBF was measured in brainstem (BS), cerebellum (CBL) and cerebrum (CBR) at baseline (BL), during HO or baseline 2 (BL2, Ca-B group), 20 min after HO (20′) or after the start of Ca-B, and 30 (30′) and 60 min (60′) after HO. Results were: Blood flow in BS (ml/100g/min, mean±SD) and MABP (mm Hg, mean±SD):
No effects of Ca-B on flow in CBL and CBR were found.
Conclusion: In spite of a significant reduction in MABP during nimodipine infusion an increased BS blood flow was found. This indicates a significant effect of nimodipine on cerebral vascular resistance.
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Odden, JP., Roll, E., Hall, C. et al. THE EFFECT OF Ca-BLOCKADE WITH NIMODIPINE ON REGIONAL CEREBRAL BLOOD FLOW AFTER EXPERIMENTAL HYPOXEMIA IN THE NEWBORN PIGLET. Pediatr Res 32, 630 (1992). https://doi.org/10.1203/00006450-199211000-00155
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DOI: https://doi.org/10.1203/00006450-199211000-00155