Abstract
The frequency dependence of attenuation of broadband ultrasound and the velocity of ultrasound passage through bone have been used as indicators of bone mineral content. BUA in adults has been shown to correlate well with established methods of measuring bone mass or density. Ultrasound has the advantages of safety, economy and portability over other techniques.
We have modified this technique for use in neonates whereby the BUA coefficient (BUAC), which normalises the BUA for the thickness of the bone, and the velocity may be measured.
The aim of this study was to see how BUAC and velocity change with gestational age (GA) and postnatal age (PNA). BUAC and velocity were measured once in 26 infants <72 hours old. Two infants were studied sequentially at twice weekly intervals.
Regression analysis showed BUAC correlated with GA (r=0.57 p<0.005) and with PNA (r=0.95 p<0.05) but not with birthweight (r=0.33). Velocity did not correlate with GA (r=0.25) or birthweight (r=0.01).
BUAC can be used to monitor bone development in neonates.
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Hamilton, P., Nassiri, D. & Weir, F. BROADBAND ULTRASOUND ATTENUATION (BUA) MEASUREMENTS IN NEONATAL BONE AND CORRELATION WITH GESTATIONAL AND POSTNATAL AGE. Pediatr Res 32, 628 (1992). https://doi.org/10.1203/00006450-199211000-00143
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DOI: https://doi.org/10.1203/00006450-199211000-00143