Abstract
During hypoglycemia (HG), cerebral blood flow (CBF) typically increases. To evaluate if this is caused by the cerebral vasodilator ADO, we used microdialysis and hydrogen clearance to measure ADO, and local CBF, respectively, in the frontal cortex of newborn piglets during normoglycemia (NG) and insulin-induced HG (blood glucose (GLU) < 1.4 mmol/l). ADO; was measured with HPLC from 20 min dialysate samples (artificial CSF containing no GLU, 2 μl/min).
RESULTS: Blood GLU correlated with ADO, (r=-0.38, p=0.003) and CBF (r= -0.42, p=0.003). HG caused a mean increase in ADO; of 90%, and in CBF of 35%. Values below (mean ± SEM):
Simultaneous perfusion of the contralateral frontal cortex with CSF containing GLU (3.6 mmol/l, n=5) caused no increase in ADO; or CBF, thereby eliminating any correlation with blood GLU concentration.
CONCLUSION: Cerebral ADO, increases during systemic HG in newborn pigs concomitant with increases in CBF, suggesting adenosine involvment in the mediation of HG hyperemia.
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Ruth, V., Gidday, J. & Park, T. INCREASED CEREBRAL INTERSTITIAL FLUID ADENOSINE CONCENTRATION (ADO1) AND BLOOD FLOW DURING HYPOGLYCEMIA. Pediatr Res 32, 612 (1992). https://doi.org/10.1203/00006450-199211000-00042
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DOI: https://doi.org/10.1203/00006450-199211000-00042