Abstract
It has been postulated that increased CNS GABA levels may play an important role in the decrease in minute ventilation observed during sustained hypoxia in the newborn. In order to determine whether the changes in ventilation during hypoxia are mediated by GABA B receptors, 12 sedated, spontaneously breathing newborn piglets (age, 5±1 d; wt, 1678±473 g) were studied. Minute ventilation (VE), arterial blood pressure (ABP) and arterial blood gases were measured in room air (RA) and at 1, 5 and 10 min of hypoxia (FiO2=0.10) before drug intervention. All measurements were repeated after an infusion of placebo (P) or the GABAB receptor blocker, CGP-35348 (100-300 mg/kg, IV) while the animals remained in hypoxia. CGP-35348 crosses the blood-brain barrier and is a potent and specific GABAB receptor blocker. Basal VE was similar in both groups. During hypoxia VE increased significantly only in the animals who received the GABAB antagonist. Changes in PaO2 and ABP were similar between groups before and after P or GABAB antagonist infusion.
These results suggest that the depression of the ventilatory response to sustained hypoxia in the neonate is in part increased CNS GABA acting through GABAB receptors.
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Huang, J., Suguihara, C., Lin, J. et al. EFFECTS OF A GABAB RECEPTOR BLOCKER (CGP-35348) ON THE VENTILATORY RESPONSE TO HYPOXIA IN NEWBORN PIGLETS. Pediatr Res 32, 611 (1992). https://doi.org/10.1203/00006450-199211000-00041
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DOI: https://doi.org/10.1203/00006450-199211000-00041