Abstract
Gastroesophageal reflux (GER) is considered to be one of the triggering factors of asthma attacks. It is believed that theophylline (TE) exacerbates GER occurrence. To evaluate the influence of TE on GER intensity in asthmatics we examined 10 stable asthmatic children aged from 3 to 11 yrs, before and during TE treatment within therapeutical TE serum range. The GER was evaluated by 24 hr esophageal pH monitoring. Pathological GER was found in 7 non treated and in B treated children. There was no statistically significant difference in GER parameters between first and second examination (p>0.05). Results were expressed as lean and ±SD. Paired t-Student test was employed for calculations.
Conclusion: The GER in asthmatic children occurs frequently and in some children theophylline aay slightly exacerbate its symptoms.
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Fyderek, K., Lis, G., Sladek, M. et al. GASTROESOPHAGEAL REFLUX AND THEOPHYLLINE IN ASTHMATIC CHILDREN. Pediatr Res 32, 610 (1992). https://doi.org/10.1203/00006450-199211000-00035
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DOI: https://doi.org/10.1203/00006450-199211000-00035