Abstract
There is a little information on hypothalamo-pituitary function in prepubertal girls with CRF. Seven prepubertal girls with CRF(3 slight or moderate and 4 in chronic dyalisis), with a mean±SD chronological age (CA) of 7.61±3.13 years (y) and 7 control (C) girls with a CA of 8.59±2.01 y, were studied. An acute standard IH-RH test as well as a prolonged one using 2 doses of 100 ug of a IH-RH (Buserelin) every 24 hours (hs). Serum LH and ESH were determined basally and at 20 and 60′ after LH-RH while serum LH, FSH and Estradiol (E2) were measured basally 24 after the first dose of a LH-RH and 4, 6 and 24 hs after the second dose. The ovarian response was considered positive whan serum E2 was ≥55 pmol/L, in at least 1 sample. Basal and post acute LH-RH levels of LH and FSH were not different from C. Serum FSH, but not LH, was significantly lower than C (p< 0.02) at 4 and 6 hs after the second a LH-RH dose (LH, IHC:0.62±0.57, 1.11±1.16, 2.49±2.94, 2.16±1.7 and 1.68±1.46; C: 0.54±0.10, 0.60±0.177, 4.06±2.29, 2.36±1.59 and 0.88±0.86; FSH, Et:2.62±1.59, 5.34±4.13, 4.98±3.86, 4.81±3.33 and 4.21±1.86, C:2.01±0.84, 5.88±2.34, 15.3±6.17, 13.7±5.86 and 2.88±1.47 U/L). A positive E2 response was sigiificantly less frequent than in C (4/7 and 6/7), p < 0.02. In C, there vas a significantly positive correlation between FSH and E2 (r=0.49, p < 0.02) but not between LH and E2 while in IRC it was significant between LH and E2 (r=0.54, p<0.01). The data suggest that girls with IRC have an alteration in FSH secretion as well as in ovarian aromatase activity as shown by the lack of E2 response and the lack of correlation between FSH and E2, which was present between LH and E2. These alterations might be expressed clinically during puberty.
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Castellano, M., Turooni, A., Charler, E. et al. 8 HYPOTHALMO-PITUTARY-OVRIAN FUNCTION IN PREPUBERTAL GIRIS WITH CHRONIC RENTAL FAILURE (CRF). Pediatr Res 32, 250 (1992). https://doi.org/10.1203/00006450-199208000-00031
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DOI: https://doi.org/10.1203/00006450-199208000-00031