Abstract
The role of cytokines in neonatal sepsis is not yet fully understood. We studied 10 septic newborns and 22 controls, aged 1-10 days. Tumor necrosis factor (TNFα), IL-1β and Interleukin 6(IL-6) concentrations were measured in EDTA-ptasma (Easia, Medgenix). In the septic group we sampled every 8 to 12 houres during 2-3 days. Maximum values arc summarized in the table. IL-6 correlated inversely with the degree of hypotension
(R=-0.562, p=0.045). With the improvement of the clinical picture both TNFα and IL-6 concentration decreased.
In conclusion, in septic newborns the highly pyrogenic mediator 1L-1β is only slightly elevated or normal. This may explane the lack of a febrile response in septic newborns.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
De Bont, E., Martens, A., Raan, J. et al. 120 EVIDENCE FOR A LOW INTERLEUKIN 1ß RESPONSE IN SEPTIC NEWBORNS. Pediatr Res 30, 648 (1991). https://doi.org/10.1203/00006450-199112000-00150
Issue Date:
DOI: https://doi.org/10.1203/00006450-199112000-00150