Abstract
ABSTRACT: To assess the effect of patent ductus arteriosus (PDA) on left ventricular output (LVO) we studied stroke volume (SV), LVO, and heart rate (HR) in 21 very low birth wt preterm neonates with clinically symptomatic PDA before and after surgical ligation. Six additional infants were also studied before PDA with left-to-right shunt was detectable by the pulsed Doppler technique. Gestational age (median and range) was 28 (24–32) wk. SV was measured by duplex Doppler and M-mode echocardiography, and LVO was calculated as product of SV and HR. LVO was 419 (305–562) mL/min/kg during symptomatic PDA. It decreased to 246 (191–292) mL/min/kg after ligation (n = 21, p < 0.001). SV was 2.69 (1.98–4.10) mL/kg during symptomatic PDA decreasing to 1.63 (1.22–1.98) mL/kg after ductal closure (n = 21, p < 0.001). HR did not change after ductal closure. In the six infants with three examinations, LVO and SV were normal before detectable ductal left-to-right shunt and after ligation, but LVO was increased by 59.5 ± 23% (mean ± SD) (p < 0.05), and SV by 60 ± 32% (p < 0.05) during symptomatic PDA. In conclusion, preterm neonates with RDS, requiring mechanical ventilation, increased LVO during symptomatic PDA by increasing their SV, and not by changing their HR.
Similar content being viewed by others
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Lindner, W., Seidel, M., Versmold, H. et al. Stroke Volume and Left Ventricular Output in Preterm Infants with Patent Ductus Arteriosus. Pediatr Res 27, 278–281 (1990). https://doi.org/10.1203/00006450-199003000-00015
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1203/00006450-199003000-00015
This article is cited by
-
A Preterm Physiologically Based Pharmacokinetic Model. Part I: Physiological Parameters and Model Building
Clinical Pharmacokinetics (2020)
-
Baseline cardiac output and its alterations during ibuprofen treatment for patent ductus arteriosus in preterm infants
BMC Pediatrics (2019)
-
Electrical velocimetry for non-invasive monitoring of the closure of the ductus arteriosus in preterm infants
European Journal of Pediatrics (2018)
-
Hemodynamic alterations recorded by electrical cardiometry during ligation of ductus arteriosus in preterm infants
European Journal of Pediatrics (2015)
-
Catecholamine-resistant hypotension and myocardial performance following patent ductus arteriosus ligation
Journal of Perinatology (2015)