Abstract
Growth hormone, IGF-1 and thyroid function were evaluated in 12 patients with chronic renal failure treated by continuous peritoneal dialysis or hemodialysis. Age ranged from 3 3/12 to 10 years (median 11 1/2, 9 Tanner I and 3 Tanner II).Mean height standard de viation score was -2-9±1.7. Nine out of 12 patients had height standard deviation scores greater than 2 SD below the mean. Growth hormone (GH) was measured by RIA every 30 min from 9PM to 5AM. Mean nocturnal GH was 3.6±1.9ng/ml. GH response to arginine (14.5±11.3 ng/ml) was 8ng/ml in 8 of 12 patients, and it did not correlate with mean nocturnal LH levels. GH response to GRF (19.8±20.3ng/ml), measured in 5 patients, correlated with mean nocturnal GH levels(r; 0.88 p 0.05). There was no correlation between IGF-I levels(0.73±0.54 UI/ml) and spontaneous or post-stimulated GH levels. In 9 patients thyroid hormone levels were:total T4 5.8±1.4ug/dl, total T3 101±34ng/dl, basal TSH 3.4±1.4uU/ml, 30-60 min TSH response to TRH 12.2±5.9 and 90 min TSH response to TRH 10.9±6.0. Free T4 levels (0.8±0.3ng/dl) were low in 5 of 9 patients. Height did not correlate with any of the hormonal levels. We conclude that, although height was low in our patients, mean nocturnal GH levels were normal. The blunted GH response to arginine in 1/3 of our patients and the delayed TSH response to TRH suggest hypothalamic-pituitary dysfunction.
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Zantleifer, D., Ferraris, J., Granillo, E. et al. GROWTH AND THYROID FUNCTION IN CHILDREN WITH CHRONIC RENAL FAILURE. Pediatr Res 28, 420 (1990). https://doi.org/10.1203/00006450-199010000-00030
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DOI: https://doi.org/10.1203/00006450-199010000-00030