Abstract
Clinical and radiological data and associated hormonal deficiencies were studied in 107 patients, with growth hormone deficiency: 46 had isolated growth hormone deficiency (1GHD)(25 males, 21 females) and 61 had multiple hypothalamic-pituitary hormone deficies (MHPD) (45 males, 16 females).
Of the patients with IGHD, 82.2% were prepubertal, 40% had micropenis, 21.4% cryptorchidism, 61.4% were born by normal delivery (1 forceps), 29.5% delivered by cesarean section, 9.1% pelvic presentation and 2 pairs of twins. 17.5% had neonatal problems, 27.3% associated anomalies, 9.1% parental consanguinity and 13.3% affected siblings.
In the group with MHPD 91.8% were prepubertal, 38.6% had micropenis, 11.1% cryptochidism, 51.8% normal delivery (4 forceps), 17.8% delivered by cesarean section, 30.4% with pelvic presentation at bird, 61.5% had neonaltal problem, 12.5% associated anomalies, 10.9% parental consanguinity and only 1 affected sibling. 14 patients with IGHD and 25 with MHPD had cranial CI-scans; abnormalities were described by the radiologist in 50% and 68%, respectively: 7.7% had empty sella, changes. The high incidence of empty sella is probably due to the small dimension of the sella in this condition. Associated hormonal deficiencies: GH + TRH (21.1%) GH +TRH + LHRH + CRF (14.0%), GH + TRH + LHRH (10.5%), GH + LHRH (10.5%), GH + TRH + CRF (8.8%).
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Estefan, V., Mendonca, B., Arnhold, I. et al. ANALYSIS OF CLINICAL DATA OF 107 PATIENTS WITH GROWTH HORMONE DEFICIENCY. Pediatr Res 28, 419 (1990). https://doi.org/10.1203/00006450-199010000-00024
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DOI: https://doi.org/10.1203/00006450-199010000-00024