Abstract
ABSTRACT: To study the effect of different high-frequency oscillatory ventilation parameters on airway pressure we measured oscillatory pressure amplitude (| Paw |) and mean airway pressure (Paw)at three sites in open-chested normal rabbits: proximal, trachea, and alveolus. Five animals were studied to test a new pleural capsule design, which was then used in two groups of animals to measure right upper (n = 4)or middle (n = 5) lobe alveolar pressures. Animals were randomly sequenced through combinations of frequency (10, 15, and 20 Hz) and fractional inspiratory time (T) (0.3 and 0.5) while normoxic and encapnic. During capsule testing, we noted that alveolar pressures increased (p < 0.05) with increasing capsule mass. suggesting that compressive forces from the capsule may alter the capsule measurement. We thus used a lowmass (430 mg) transducer system in the rabbit high-frequency oscillatory ventilation experiments. Using multifactorial analysis of variance, we found significant main effects of Ti on Paw, and of measurement site on both |Paw| and Paw (p < 0.009). Frequency did not influence variations in either |Paw| Paw. For both Ti settings, alveolar upper lobe Paw was lower compared with that of the middle lobe (p < 0.0005). Lengthening Ti (03 to 0.5) increased tracheal Paw in each capsule group (p < 0.0005). At Ti = 0.5, tracheal Paw exceeded Paw measured proximally (p < 0.05). Our data support in vivo alveolar Paw inhomogeneity and demonstrate significant changes in pressures within the lung related to Ti during high-frequency oscillatory ventilation.
Similar content being viewed by others
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Gerstmann, D., Fouke, J., Winter, D. et al. Proximal, Tracheal, and Alveolar Pressures during High-Frequency Oscillatory Ventilation in a Normal Rabbit Model. Pediatr Res 28, 367–373 (1990). https://doi.org/10.1203/00006450-199010000-00013
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1203/00006450-199010000-00013
This article is cited by
-
High-frequency ventilation in preterm infants and neonates
Pediatric Research (2023)
-
Tidal volume significantly affects oxygenation in healthy pigs during high-frequency oscillatory ventilation compared to conventional ventilation
BioMedical Engineering OnLine (2022)
-
Effect of the I/E ratio on CO2 removal during high-frequency oscillatory ventilation with volume guarantee in a neonatal animal model of RDS
European Journal of Pediatrics (2016)
-
Changes in lung volume and ventilation following transition from invasive to noninvasive respiratory support and prone positioning in preterm infants
Pediatric Research (2015)