Abstract
Patients (pts) with ESRD frequently have atherogenic lipoprotein profiles. In early atherosclerotic lesions, monocyte-derived macrophages develop into foam cells through accumulation of cholesterol (Chol). We measured lipoprotein profiles in plasma and lipids in MO of 6 pts (age 14.4±3.2 y) treated by peritoneal dialysis (PD), 10 pts (age 15.4±4.3 y) treated by hemodialysis (HD) and 7 controls (Ctr; age 22.8±10.4 y) . PD and HD pts had elevated levels of plasma triglycerides (TG), plasma Chol (PD only), and Chol in the VLDL and LDL fraction (PD only), whereas HDL-Chol levels were low. Apolipoprotein (APO) B, but not APO AI, plasma levels were significantly elevated only in PD pts. In MO, we measured free Chol (FC), Chol esters (CE), and TG (MO/TG). Results (ug/mg cell protein; x±SD):
We conclude that increased lipoprotein lipid levels are not associated with lipid accumulation in MO. Only pts treated with HD have a significant decrease of FC in MO.
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Querfeld, U., Wendtland, J., Hodenberg, E. et al. 136 LIPID LEVELS IN PLASMA AND MONOCYTES (MO) IN CHILDREN WITH END-STAGE RENAL DISEASE (ESRD). Pediatr Res 28, 299 (1990). https://doi.org/10.1203/00006450-199009000-00160
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DOI: https://doi.org/10.1203/00006450-199009000-00160