Abstract
We compared a single large dose of intravenous gamma globulin (IVGG) with the standard regimen of four smaller daily doses in reducing systemic inflammation and coronary artery abnormalities in 548 patients (pts) with acute KD within the first 10 days of fever in 7 U.S. university medical centers. Pts were randomly assigned either to a single-infusion (273 pts) (IVGG, 2 g/kg, over 10 hours), or to four-infusion (275 pts) (400 mg/kg/day for 4 consecutive days); both received aspirin, 100 mg/kg/day, through illness day 14, then 3 to 5 mg/kg/day. The groups were similar at enrollment. In the single-infusion group, mean decrease in temperature from study day 1-2 was greater (p<.0001) and albumin (p=.02) and α-1-antitrypsin (p=.05) improved more rapidly. Echocardiograms interpreted blindly and independently by two readers showed coronary artery abnormalities on one or more studies in 6.4% of pts overall: single-infusion vs four-infusion = 4.6% vs 8.2%, respectively, including those with abnormal echocardiograms at enrollment and 3.4% vs 5.5% excluding those with initial abnormalities. Side effects were equal and mild. Single infusion IVGG is safe and effective, reducing fever, inflammation and coronary artery abnormalities more than the 4 day regimen.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Melish, M. 103 IVGG TREATMENT OF KAWASAKI SYNDROME (KD). Pediatr Res 28, 294 (1990). https://doi.org/10.1203/00006450-199009000-00127
Issue Date:
DOI: https://doi.org/10.1203/00006450-199009000-00127