Abstract
Increased glucose utilisation and decreased mobilisation of fat and subsequent lack of free fatty acids (FFA) and ketone bodies as alternative substrates, in theory, may be factors causing hypogiycaemia in IDM's.
We studied the metabolic adaptation in 15 infants of strictly controlled diabetic mothers. The infants had a gestational age of 38 ± 2 wk (mean ± SD) and a birthveight of 3300 ± 750 g and were studied at a postnatal age ranging from 3-16 hours. Glucose disappearance rate (Rd) anc glucose production rate (EGPR) were measured with the prime dose-constant rate technique using 6, 6-dideutero glucose, prior to any oral feeding. Infants received a low dose glucose infusion (mean 3.2 mg/kg/min).
Results: Rd ranged from 3.8 to 8.2 mg/kg/min (mean 5.2), EGPR ranged from 0 to 4.8 mg/kg/min (mean 1.8). Plasma BOH butyrate concentration ranged from 0.02 to 0.4 mmol/l. FFA ranged from 61 to 621 umol/l.
Conclusion: In the presence of a low dose glucose infusion IDM's of strictly controlled diabetic mothers appear to have a normal glucose turnover postnatally. The appearance of FFA and ketone bodies into the circulation, however, seem to be impaired.
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Baarsma, R., Chapman, T., Berger, R. et al. 37 METABOLIC ADAPTATION OF INFANTS OF DIABETIC MOTHERS (IDM) ON THE FIRST DAY OF LIFE. Pediatr Res 28, 283 (1990). https://doi.org/10.1203/00006450-199009000-00061
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DOI: https://doi.org/10.1203/00006450-199009000-00061