Abstract
There are few data in children on the homeostatic responses of the colon to Na depletion. We have studied 8 ileostomy patients (median age 160d, range 45-1030, median weight 3.57 kg, range 3-11.5), before and after the ileostomy closure, using non-equilibrium rectal dialysis and 24hr Na balances. Rectal Na absorption and K secretion (nmol/min/cm2) were significantly higher in the children with a negative or low positive Na balance (n=7, median Na balance +0.05 mmol/kg/24hr; median Na absorption 238; median K secretion 89) compared with those with a large positive sodium balance (n=6, median Na balance +2.42 mmol/kg/24hr, p<0.05; median. Na absorption 138, p<0.05; median K secretion 42, p<0.05). Whilst median rectal Na absorption and K secretion before and after closure of the ileostomy were-similar and not different from controls, Cl absorption (nmol/min/cm2) was significantly lower before (median 139, range 65-231) than after (median 175, range 134-259, p<0.05). These data indicate that rectal, and presumably colonic, electrolyte transport is enhanced in children with a negative or low Na balance, and that Cl but not Na absorption is depressed by the temporary diversion of ileal effluent.
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Finkel, Y., Jenkins, H. THE ROLE OF THE COLON IN MAINTAINING SODIUM HOMEOSTASIS IN YOUNG CHILDREN. Pediatr Res 27, 534 (1990). https://doi.org/10.1203/00006450-199005000-00052
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DOI: https://doi.org/10.1203/00006450-199005000-00052