Abstract
We have shown that whole-body turnover of tRNA, rRNA and mRNA in man can be determined by measuring the excretion of specific modified RNA catabolites (Sander et al (1986) Clin Sci 71: 367-374). Our method is suitable for assessing metabolic status and its alteration e.g. by nutritional influences (Schöch et al (1988) Ped Res 24: 270 and 419). We therefore looked for animal models apt to improve the results we have already obtained in man. As we have observed, the overall principle holds true for all species investigated so far, although with species-specific differences in the suitability of the different turnover markers (Table), the use of animal models thus presupposing selection of the appropriate marker(s):
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Schöch, G., Topp, H., Sander, G. et al. NONINVASIVE ASSESSMENT OF tRNA-, rRHA- AND mRNA-TURNOVER: COMPARATIVE HUMAN AND ANIMAL EXPERIMENTS. Pediatr Res 26, 527 (1989). https://doi.org/10.1203/00006450-198911000-00167
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DOI: https://doi.org/10.1203/00006450-198911000-00167