Abstract
ABSTRACT: Changes in the normal hormonal regulation of linear growth which lead to growth failure in children with chronic renal failure (CRF) are not well understood. Previous studies indicate that serum levels of growth hormone and IGF-I and II are normal or elevated in this population; and that serum levels of poorly defined inhibitors of IGF action are increased. Using a recently developed RIA for the 25-kD IGF-binding protein (IGF-BP25), we report significant elevations of this protein in children with CRF when compared to age- and sex-matched controls. IGF-BP25 levels correlate positively with IGF-binding activity in both populations, indicating that the RIA reflects levels of bioactive protein. Although the variation of serum IGF-BP25 with chronologic age and IGF levels are preserved in CRF, the quantitative interrelationships are disrupted. Levels of the 53-kD IGF-binding protein, an IGFbinding protein derived from the high mol wt IGF complex, were also found to be elevated in the CRF population and, unlike in the control population, did not vary with age or IGF levels. IGF-BP25 has been shown to inhibit IGF mitogenic action in vitro. Our finding of elevated levels of IGF-BP25 in children with CRF suggests that this protein may play a role in the growth retardation of pediatric chronic renal failure. The significance of the elevated IGFBP53 levels in CRF remains uncertain.
Similar content being viewed by others
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Lee, P., Hintz, R., Sperry, J. et al. IGF Binding Proteins in Growth-Retarded Children with Chronic Renal Failure. Pediatr Res 26, 308–315 (1989). https://doi.org/10.1203/00006450-198910000-00005
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1203/00006450-198910000-00005
This article is cited by
-
Modulation of growth factors by growth hormone in children with chronic renal failure
Kidney International (1997)
-
Growth promoting effects of growth hormone and IGF-I are additive in experimental uremia
Kidney International (1996)
-
Evaluation of clinical and laboratory parameters during 2 years of growth hormone treatment in prepubertal children with chronic renal failure
European Journal of Pediatrics (1996)
-
Serum insulin-like growth factors and their binding proteins in children with end-stage renal disease
Pediatric Nephrology (1996)
-
Pharmacokinetics of recombinant human insulin-like growth factor-1 in dialysis patients
Kidney International (1995)