Abstract
Preliminary reports suggest that intravenous immunoglobulins may be helpful in the treatment of adult patients with Crohn's disease (CD) and ulcerative colitis (UC; Lancet I:170, 1987). However, the efficacy of this treatment in children with chronic inflammatory bowel disease (IBD) is unknown. Therefore 18 patients with histologically confirmed IBD (CD=12, UC=6) were treated by 7S-Immunoglubulin (0,4 g/kg for 7 consecutive days) in 8 pediatric hospitals in the F.R.G. 10 children suffered from relapses and 8 from newly diagnosed IBD. 5 patients showed a marked improvement already short time after therapy was started. 4 children have still been in remission for several months. In contrast 13 children did not benefit from the immunoglobulins. 4 of them even deteriorated and needed additional treatment with 5-ASA and steroids. Side effects of the therapy with immunoglobulins were anaphylaxis (1x) and fever (1x). Further investigations are necessary to determine the benefit of immunoglobulin therapy of childhood IBD.
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Teufel, M., Niessen, K., Behrens, R. et al. TREATMENT OF CHILDOOD CHRONIC INFLAMMATORY BOWEL DISEASE WITH 7S-IMMUNOGLOBULIN. Pediatr Res 26, 268 (1989). https://doi.org/10.1203/00006450-198909000-00028
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DOI: https://doi.org/10.1203/00006450-198909000-00028