Abstract
In order to increase sodium and water absorption from oral rehydration solutions new formulations with different organic solutes, electrolytes and aminoacids have been proposed. So far, there are no obvious advantages of these formulation over the ORS-WHO.
We studied water and electrolyte absorption with a continuous perfusion model in rat gut (Wistar, 28 days, weight: 933.7g) comparing WHO solution (Na: 90mEq/l; K: 20mEq/l; Glucose: 111mM; CO3HNa: 30mM) with a glutamine based solution (Na: 90mEq/l; K: 20mEq/l; Glutamine: 110mM; CO3HNa: 30mM). The proximal end of the canula was inserted immediately distal to Treitz (43 ± 9.4cm). The first 60′ perfusion volume was discarded to attain steady-state equilibration (0.35ml/′). Perfusates were collected in 4 periods of 15′ (variation between periods less than 10%) Net absorption of water and electrolytes was estimated with PEG4000. The results, average of the 4 periods, are shown in the table:
The replacement of glucose by glutamine in oral rehydration solution increased significantly net water and sodium absorption in the experimental condition described. Glutamine effect could be different from other organic solutes (glucose, glicine, dipeptides, etc). The elucidation of this mechanism and its potential clinical application is subject of present on going research.
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Torres Agero, M., Ulrich, R., Carmuega, E. et al. SUPER GLUTAMINE ORAL REHYDRATION SOLUTION. ITS EFFECT ON SODIUM AND WATER ABSORPTION IN PERFUSED RAT GUT. Pediatr Res 26, 165 (1989). https://doi.org/10.1203/00006450-198908000-00040
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DOI: https://doi.org/10.1203/00006450-198908000-00040