Abstract
We determined GH release after 2 GRF tests (synthetic GRF, 1-44s, Sanofi, France) with 1 (GRF1) and 2 (GRF2) μg/Kg i.v. in 14 clinically prepubertal children affected by a partial (GH peak between 3 and 7 ng/ml) (PIGHD) (6 children) or total (GH peak < 3 ng/ml) (TIGHD) (8 children) isolated idiopatic GH-deficiency. GRF tests were performed in a casual succession with a 24 hour interval, at 9 a. m.. 9 children had a GH peak > 10 ng/ml (R): 6 children to both GRF tests and 3 children only to GRF1 (in 1 case it was the 1st test and in 2 cases the 2nd one); 5 children had a GH peak < 10 ng/ml to both GRF tests (no-R). All PIGHD and 3 TIGHD were in R-group. GH peak was higher in PIGHD (18.7 ± 9.2 ng/ml) than in TIGHD (9.2 ± 6.1 ng/ml) (p < 0.05). No significant correlation was found between GH peaks during conventional tests and GRF tests in R-group. Our data show that: -1 μg/Kg of GRF i.v. is able to evoke the serun maximal GH increase -there is no difference in GH peak according to the sequence of GRF stimulation and to the sex -R and no-R show a similar pattern of growth both before and during GH therapy-chronological, height and bone age do not affect the GH release after GRF -TIGHD is more frequently pituitary-dependent than PIGHD. We conclude that GRF test is not a reproducible test in GH-deficient children; therefore it is necessary to repeat it at least twice to exclude a hypophyseal source of GH-deficiency.
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Cavallo, L., Acquafredda, A., Laforgia, N. et al. 81 EVALUATION OF GRF TEST IN GH-DEFICIENT CHILDREN. Pediatr Res 24, 530 (1988). https://doi.org/10.1203/00006450-198810000-00102
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DOI: https://doi.org/10.1203/00006450-198810000-00102