Abstract
The GH response to GHRH and 24 hrs. integrated concentration have been measured in 25 prepubertal children. 12 of them (group 1) were affected by CGD (short stature, normal height velocity, delayed bone age and GH response to pharmacological stimuli > 10 ng/ml); 7 girls (group 2) had gonadal dysgenesis (with normal GH response to pharmacological stimuli) and 6 patients (group 3) were GH deficient. Mean IC-GH and peak GH serum level in response to GHRH stimulation were significantly different among the 3 groups (IC-GH:6.76 in group 1 vs. 4.7 in group 2 vs. 1.64 ng/ml in group 3, p < 0.002; peak GH 36.6 vs. 21.9 vs. 4.8 ng/ml, p < 0.002). Moreover the GH Δ values and the area under the curve after GHRH were significantly lower in group 2 and 3 compared to group I (Δ :10.5 and 4.1 vs. 32 ng/ml; area:511 and 291 vs. 1771 ng/ml/90'). No differences were found between group 2 and 3. Considering the 25 patients althogether, a positive correlation was present between GH peak. Δ and area values after GHRH and IC-GH (r:0.6, 0.56 and 0.57 respectively). The results of the present study show that : 1) An impairment in GH secretion is often present in patients with Turner syndrome also before puberty. 2) This alteration is more evident in the GH response to GHRH being its Δ and area values not different from those of GH deficient children. IC-GH levels even if lower than in CGD group as a mean, show an overlapping in the single values in these 2 groups.
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Volta, C., Ghizzoni, L., Laborghini, A. et al. 80 24 HRS. GROWTH HORNONE INTEGRATED COMCENTRATION (IC-GH) AND GH RESPONSE TO GH-RELEASING HORNONE (GRAH) IN CONSIITUTIONAL GRWOTH DELAY (CGD), TRUNER SYNDROME AND GH DEFICIENCY. Pediatr Res 24, 530 (1988). https://doi.org/10.1203/00006450-198810000-00101
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DOI: https://doi.org/10.1203/00006450-198810000-00101