Abstract
To search for the presence of morphostructural abnormalities of the hypothalamus - pituitary region in GHD children MRI was performed in 28 IGHD pts (21M, 7F, age 10.1±3.4, range 4.2-18) and in 15 healthy age matched controls (10M, 5F, age 8.3±2.9, range 4 to 12.4). Isolated GHD had been demonstrated in 19/28 pts, multiple pituitary hormones deficiency (MPHD) in 9/28; none had ADH deficiency. Hypothalamic or pituitaric deficiency was equally distributed in the two groups. We evaluated: presence, size, shape of the pituitary stalk; pituitary and sella volume calculated according to Di Chiro. MRI revealed that in 18/28 pts the pituitary stalk was separate from the gland (Group 1); in 14/18 pts the reurohypophysis was dislocated in the hypothalamic region; the pituitary and sella volumes were markedly reduced in all CHD pts compared with controls. No special endocrinological feature characterized the 2 groups.
Conclusions: GHD pts frequently present some degree of abnormality of the hypothalamus-pituitary region; this picture is equally distributed between isolated GHD and MPHD pts. The observed dislocation of the neurohypophysis does not induce ADH deficiency.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Pellini, C., Di Natale, B., Petecca, C. et al. 73 MR IMAGING (MRI) OF PITUITARY GLAND AND STALK IN MIOPATHIC GROWTH HORMONE DEFICIENCY (IGHD). Pediatr Res 24, 529 (1988). https://doi.org/10.1203/00006450-198810000-00094
Issue Date:
DOI: https://doi.org/10.1203/00006450-198810000-00094