Abstract
Long-term effects of BMT during childhood are still to be defined according to the type of BMT (ALLO BMT versus AUTO BMT), the type of preparation regimens (Total Body Irradiation: TBI. Total Lymphoid Irradiation:TLI) and the possible Graft vs Host Disease (GVH). 32 patients (21 B, 11 G) have been followed up for at least one year after transplantation (Leukaemia:21, Lymphoma:3, Tumors:3, Aplastic aneamia:2, Metabolic:3). 11 have been previously given cerebral irradiation (CR). Age at the BMT was 6.7 y (0.4-13.5 y). 20 received ALLO BMT and 12 AUTO BMT. Auxological evaluation was performed at 1 year for all, at 2 in 21 and at 3 in 8. Results are summarized in the table (in SOS according to SEMPE)
*181 given in 6 or more fractions in 21
Height loss was quite similar among patients given TBI, even in the absence of CR. The only regimen leading to normal growth was AUTO BMT without TBI. Our data support a deleterious effect of TBI, even if fractionated, in association with ALLO BMT. The reduction in velocity was not correlated with GH secretion (pharmacological and nocturnal) or thyroid abnormalities. A direct effect of either TBI or GVH on cartilage is likely to explain these results.
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Leheup, B., Bordigoni, P., Olive, D. et al. 60 AUXOLOGICAL FOLLOW-UP OF 32 PATIENTS AFTER BONE MARROW TRANSPLANTATION (BMT) BEFORE 14 YEARS OF LIFE. Pediatr Res 24, 527 (1988). https://doi.org/10.1203/00006450-198810000-00081
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DOI: https://doi.org/10.1203/00006450-198810000-00081