Abstract
To further understand the pattern of cerebral blood flow during neonatal ECMO, we performed serial measurements of the peak systolic (PSFV), end-diastolic (EDFV), and mean blood flow velocities (MFV) of the anterior cerebral arteries in 8 infants pre-, during, and post-ECMO. Mean ± SD values of the MFV increased from 9.4 ± 2.4 cm/sec pre-ECMO to 13.0 ± 2.2 cm/sec (p<0.01) during maximal bypass flow (91 ± 17 ml/min/kg). Simultaneously, the mean EDFV increased from 4.0 ± 1.9 to 7.2 ± 1.7 an/ sec (p<0.01), the mean PSFV increased from 10.3 ± 1.9 to 12.8 ± 3.1 cm/sec (NS), and the pulsatillty index (PI: PSFV-EDFV/PSFV) decreased from 0.63 ± 0.12 to 0.45 ± 0.05 (p<0.01). Post-ECMO values of MFV (8.4 ± 2.5 cm/sec), EDFV (3.8 ± 1.4 cm/sec), PSFV (9.3 ± 2.5 cm/sec), and PI (0.60 ± 0.08) were comparable to pre-ECMO values. During weaning from ECMO the PI increased steadily with a concomitant decrease of the MFV.
These data indicate that during neonatal ECMO cerebral perfusion is higher and cerebral vascular resistance lower than pre-and post-ECMO and that these changes are related to the amount of bypass used.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Van Bel, F., Walther, F., Gangitano, E. et al. 28 CHANGES IN CEREBRAL PERFUSION DURING NEONATAL EXTRA- CORPOREAL MEMBRANE OXYGENATION. Pediatr Res 24, 265 (1988). https://doi.org/10.1203/00006450-198808000-00054
Issue Date:
DOI: https://doi.org/10.1203/00006450-198808000-00054