Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

2 URATE NEPHROPATHY: A RARE BUT NOT VANISHED ENTITY

Abstract

Chronic urate nephropathy in the past decades was a frequent cause of renal failure in gouty patients but this entity has become very rare in the recent years and in many centers of hemodialysis the registries of chronic renal failure populations do not list gouty nephropathy as a cause.

Some authors even discuss the existence of gouty nephropathy (1). In our series of 140 patients with primary gout (128 M, 12 F) including 20 patinets with late onset (over 65 years) of the disease (15 M, 5 F) we never observed renal insufficiency with serum creatinine over 1.5 mg/dl; but the urate nephropathy exist also as a rare familial form, inherited in a autosomal dominant manner and, more rarely, as an idiopathic form, without clinical evidence of gouty arthritis.

Recently we observed an idiopathic form of this disease in a male patient, 51 years old, who presented a middle renal insufficiency (serum creatinine over 2.0 mg/dl and albuminuria).

Ultrasonic kidney study and C.A.T. have shown numerous microcysts in the cortical of the kidney, but only the needle biopsy has confirmed the urate nature of the interstitial chronic nephropathy.

1- L.H. Beck Kidney Int. 30 (1986) 280-286.

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Carcassi, A., De Mia, M. 2 URATE NEPHROPATHY: A RARE BUT NOT VANISHED ENTITY. Pediatr Res 24, 111 (1988). https://doi.org/10.1203/00006450-198807000-00026

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1203/00006450-198807000-00026

Search

Quick links