Abstract
Primary hypomagnesemia (PH) Is a rare condition, where hypocalcemia and hyperphosphatemia are a consequence of the hypomagnesemia. Two patients with HH admitted to the Children's Hospital with seizures are reported. Patient 1: A 12 month old boy with a history of seizures ncn responsive to anticonvulsivant therapy during a period of 4 months. On admission serum Ca: 7mg/dl, P: 7.3 mg/dl, alkalinephosphatase: 173 TU/l, Mg: 0.46 mg/dl. After administration of 200 U of IV PH he showed an elevation of serum Ca as well as urine phosphate. These data suggest a good end organ response of the bones and the kidneys. He was treated with IV Mg 6 mEq/day with a good clinical and laboratory response. Patient 2: A two month old girl was admitted at the Hospital because of seizures. She did have two sibling with seizures who died during the neonatal period. On admission serum Ca: 7.3 mg/dl, P: 7 mg/dl, alkaline phoephatase: 240 IU/l, Mg: 0.4 mg/dl, PTH: 0.437 pg/ml (NV: 0221 ± 0.075 pg/ml). The high PTH levels suggests an end organ resistance. She was treated with IV Mg 4 mEq/d with good clinical and lab response. The diagnosis of FH was supported in both cases by recurrent hypomegnesemia when treatment was discontinued and its normalization when treatment was restored. With Mg treatment both patients had a good clinical and neurological evolution. A failure in the intestinal transport of Mg could be the cause of this disease. A lack of PTH secretion or an end organ failure to the PTH action are determinants of hypocalcemia, when hypomagnesemia is present.
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Mendilaharzu, H., Ferrarl, P., Bengolea, V. et al. 29. PRIMARY HYPOMAGNESEMIA: A REPORT OF TWO PATIENTS. Pediatr Res 23, 652 (1988). https://doi.org/10.1203/00006450-198806000-00052
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DOI: https://doi.org/10.1203/00006450-198806000-00052