Arrest in somatic and sexuel development in patientswith CD is well known. To elucidate the influence of pituitary hormones as GH and the gonadotropins in this process we measured nocturnal secretion of GH, LH, and FSH in 3 patients (1 girl, 12 years old, prepubertal, and 2 boys, 13 and 17 years old) before therapy and during remission. The boys had developed puberty stages 3 and (according to Tanner).
Blood was collected every 20 minutes from 10 p.m. to 6 a.m., sleep was registrated by observation. In all patients GH-secration during the acute phase of the illness showed no significant nocturnal peaks. Nevertheless baseline GH levels v.1 are slightly elevated in atleast one patient. During remission all patients showed restored nocturnal GH-peaks. The gonadotropin levels in the prepubertal girl were undetectable before therapy as well as in remission, no nocturnal pulses were visible. The 2 pubertal boys demonstrafcd typical pulsatile nocturnal LH secretion. FSH levels wore in the pubertal range as well before therapy and during remission. Whether the malnourished situation, the catnbolic state or other factors caused the GH-peak depression is yet not clear. In our patients with CD we saw no differences between the spontaneous gonadotropin secretion before therapy and during remission as it is known in other catabolic situotiones or instance in anorexia nervosa.
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Beyer, P., Brock, C. & Richter, A. NOCTURIAL SECRETION OF GROWTH HORMONE (CH) AND GOHADOTROPINS IN 3 PATIENTS WITH CROHN (CD) BEFORE THERAPY AND DURING REMISSION. Pediatr Res 23, 138 (1988) doi:10.1203/00006450-198801000-00219