Abstract
Neonatal maladaptation is frequent in LGA infants. To evaluate adrenocortical function in LGA's at birth and during postnatal adaptation, plasma aldosterone (Aldo), 11-deoxycorticosterone (DOC) corticosterone (B), progesterone, 17-hydroxyprogesterone, 11-deoxycortisol, Cortisol (F) and cortisone (E) were simultaneously followed in 9 term vaginally delivered LGA (>97.perc.) by multisteroid analysis by specific RIAs after Sephadex LH-20 chromatography in 250 μl samples. 12 appropriate for gest.age (AGA) infants served as controls. All mothers were healthy with no diabetes or gestosis, no primiparae. Relevant results (LGA/AGA mean values in ng/ml):
Obviously, LGA infants are maintaining high Aldo levels, whereas DOC levels were lower than in AGA. High fetal glucocorticoids (B, F, E) in LGA reflect either increased fetal stress and/or placental transfer of high maternal steroids. Additionally,elevated glucocorticoids (B,F) from 12 h to 7 d point to a more stressful postnatal adaptation in LGA newborns.
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Dorr, H., Versmold, H., Sippell, W. et al. LONGITUDINAL STUDY OF ADRENOCORTICAL STEROIDS IN LARGE FOR GESTATIONAL AGE (LCA) INFANTS AT BIRTH AND DURING NEONATAL PERIOD. Pediatr Res 23, 130 (1988). https://doi.org/10.1203/00006450-198801000-00172
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DOI: https://doi.org/10.1203/00006450-198801000-00172