Abstract
An increase in serum iron levels and a decrease in serum unsaturated iron binding capacity (uIBC) were noted following the administration of cisplatinum to 9 children with malignancies. The mean serum iron concentration increased from a pretreatment level of 75.7±30.5 ug/ml to a post treatment level of 162.1±65.3 ug/ml with the first cisplatinum treatment course(p<0.004). The uIBC concomittantly decreased from 181.9±33.7 ug/ml to 86.4 ± 44.6 ug/ml(p<0.0005). Cummulative effect was noted following subsequent courses. The levels returned to baseline values within 2-4 months following cessation of therapy in 6 children in whom follow up data was available. It is possible that this reversal of the iron/uIBC ratio is the result of cisplatinum competition for iron binding sites to proteins.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kletter, G., Parks, B., Bhatnagar, A. et al. ELEVATED SERUM IRON LEVELS FOLLOWING ADMINISTRATION OF CISPLATINUM. Pediatr Res 21 (Suppl 4), 300 (1987). https://doi.org/10.1203/00006450-198704010-00798
Issue Date:
DOI: https://doi.org/10.1203/00006450-198704010-00798