Abstract
Despite the mucosal hyperplasia that follows massive small bowel resection, changes in absorptive function are thought not to parallel changes in mucosal mass. This is described as “functional immaturity” of the new enterocytes. We approximated unidirectional glucose uptake using an inert glucose analogue, 3-0-Methylglucose(3MG). The study included 24 160 gram male Sprague-Dauley rats, half of which underwent 80% jejunoileal resection, the remainder being sham-operated. Six animals of each group were studied at post-op day 3 and six at post-op day 10. The unidirectional 3MG uptake was determined utilizing intestinal rings incubated for 3 minutes in KRB buffer at various concentrations of 3MG. The J value in resected animals is shown below in both duodenum and ileum at 10 mM concentration. Value x1000+SEM
Despite a marked increase in mucosal mass, there was no significant difference in 3MG uptake between day 3 and day 10. No functional immaturity of the enterocytes at day 10 was apparent, suggesting that the marked increase in mucosal mass following resection is accompanied by the corresponding increase in glucose absorption.
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Erdman, S., Park, J., Grandjean, C. et al. LACK OF FUNCTIONAL IMMATURITY OF THE GLUCOSE TRANSPORT SYSTEM FOLLOWING SMALL BOWEL RESECTION IN THE RAT. Pediatr Res 21 (Suppl 4), 266 (1987). https://doi.org/10.1203/00006450-198704010-00596
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DOI: https://doi.org/10.1203/00006450-198704010-00596