Abstract
Atrial natriuretic polypeptide (ANP), a substance secreted by mammalian atria in response to increased atrial pressure or volume, has potent natriuretic, diuretic and vasodilatory properties. As measured by bioassay, the ANP content in atria from adult hypertensive S/JR rats has been reported to be increased in comparison to that of adult nonhypertensive R/JR rats. In addition, the S/JR rat has been reported to be less sensitive than the R/JR rat to atrial extracts injected intravenously (Snajdar & Rapp, 1985). However, we are unaware of any data on atrial IRANP concentrations in Dahl rats of any age. Because of the potential role that ANP might play in the development of salt-sensitive hypertension, we examined the ontogeny of IRANP concentrations in S/JR and R/JR rats from 5 to 51 days of age. Atria were extracted and ANP concentrations were measured by RIA. Lactating dams consumed a diet containing 0.15% NaCl and the rat pups were weaned to the same diet. Analysis of our results to date demonstrate a significant effect of age on IRANP concentration (p<0.01) with peak concentrations occurring at 15 days of age, but no significant influence of strain. These results suggest that: 1) atrial IRANP concentrations in both strains of Dahl rat increase between 5 and 15 days of age and then decline, and 2) no difference in atrial IRANP concentration is seen between the immature S/JR and R/JR Dahl rat.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Wilson, T., Dolan, L., Dobrozsi, D. et al. IMMUNOREACTIVE ATRIAL NATRIURETIC POLYPEPTIDE (IRANP) CONCENTRATION IN ATRIA FROM DEVELOPING SALT-SENSITIVE (S/JR) AND SALT-RESISTANT (R/JR) DAHL RATS. Pediatr Res 21 (Suppl 4), 224 (1987). https://doi.org/10.1203/00006450-198704010-00348
Issue Date:
DOI: https://doi.org/10.1203/00006450-198704010-00348