Abstract
EP regulates erythropoiesis in the fetus (F), newborn (N), and juvenile (J). Delineating the developmental changes that occur in EP kinetics would be important in explaining the possible role that EP plays in the pathophysiology of anemia and polycythemia. We investigated the differences in EP kinetics in the F, N, and J by infusing 35S labelled human Ep into 5 F (126 day), 6 N (7-8 day), and 4 J (270 day) sheep. After bolus infusion, timed blood samples were obtained and the plasma was precipitated with 20% trichloroacetic acid. Plasma half life (T½), volume of distribution (Vd) and EP clearance (Cep) were determined from the beta decay curves of ln EP vs time:
F Ep T½ is prolonged when compared to N and J (p<0.05). T½ decreases as F and N mature (r= -0.53, p<0.05). We conclude that the F, N, and J have differences in Ep kinetics. These differences, which reflect maturational processes, may play role in the pathophysiology of anemia and polycythemia.
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Malone, T., Widness, J., Mufson, A. et al. ONTOGENY OF ERYTHROPOIETIN (EP) KINETICS IN FETAL, NEWBORN, AND JUVENILE SHEEP. Pediatr Res 21 (Suppl 4), 218 (1987). https://doi.org/10.1203/00006450-198704010-00309
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DOI: https://doi.org/10.1203/00006450-198704010-00309