Abstract
Though hyp has been shown to stimulate adrenal medullary CA release and raise plasma CA concentrations, it is unclear whether acidosis influences the magnitude of this response. Eleven chronically catheterized late gestation(0.8) fetal lambs in utero were investigated during a baseline control period and following the onset of umbilical cord constriction-induced hypoxemia (PO2=5-15 torr). The data were segregated based upon the fall in pH. Plasma CA rose in response to hypoxemia, but were potentiated by the development of acidosis (pH=7.19±.02). Baseline NE(487±113 pg/ml) increased to 1386±127 pg/ml (p<.0001) in response to hyp alone but rose to 6726±1289 pg/ml (p<.05) in the presence of hyp+acidosis. Hyp increased plasma E from 99±36 pg/ml to 512±81 pg/ml (p<.001). However, an additional 9-fold increase (p<.05) was noted when hyp was combined with acidosis (E=4311±1449 pg/ml). Thus, acidosis significantly potentiates the magnitude of the plasma CA response to hyp in the late gestation fetus.
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Lewis, A., Sadeghi, M. ACIDEMIA POTENTIATES THE PLASMA CATHECHOLAMINE(CA) RESPONSE TO HYPOXEMIA(HYP) IN FETAL SHEEP. Pediatr Res 21 (Suppl 4), 217 (1987). https://doi.org/10.1203/00006450-198704010-00307
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DOI: https://doi.org/10.1203/00006450-198704010-00307