Abstract
Our previous work suggests rat intestinal perfusion is a useful model for studying ORS efficacy. In this study we compared water and Na movement in rat (whole small intestine in situ) and human (jejunal triple lumen) perfusion models to establish whether parallelism exists. Test ORS include WHO recommended ORS (Na90, Cl 80, K20, HCO330, glu 111mmol/l), British National Formulary BNF-ORS (Na35, CI37, K20, HCO318, glu 200) an experimental ORS EXP-ORS (Na60, C150, K20, HC0330, glu 111) and isotonic saline. In the rat all ORS promoted water absorption. EXP-ORS (176±10 μl/min/g;n= 6) was superior to BNF-ORS (109±8, n=12) and WHO-ORS (107±11, n=7; p< 0.01). In the human model, all ORS promoted water absorption and the profile was similar to that seen in the rat; EXP-ORS (3.3±0.4 μl/min/30cm, n=7), WHO (2.7±0.3, n=7) and BNF-ORS (2.4±0.3, n=6), although no single ORS was superior. All ORS were superior to isotonic saline and Na movement was related to ORS Na concentration. In rat, No, absorption was greater from WHO-ORS (7±2 μmol/l/g) than EXP-ORS (4±0.5;p<0.01). Similarly, in human Na absorption was greater from WHO-ORS than EXP-ORS (185±33 vs 126±29 μM/min/30cm;p< 0.05). In these studies Ka and water movement from ORS in rat and human models are similar and suggest that animal models may be of value in optimising ORS for treatment of acute diarrhoea.
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Elliott, E., Hunt, J., Watson, A. et al. 76. ORAL REHYDRATION SOLUTIONS (ORS): ASSESSMENT IN HUMAN AND ANIMAL MODELS OF INTESTINAL PERFUSION. Pediatr Res 22, 108 (1987). https://doi.org/10.1203/00006450-198707000-00097
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DOI: https://doi.org/10.1203/00006450-198707000-00097