Abstract
Three major VZV GPs [1, 2, 3] have been identified. We used a Dot-ELISA to determine the geometric mean titer [GMT] of antibody to these GPs in children with ALL who had past natural varicella (NV) or who received the live attenuated varicella vaccine(LAVV). In vaccinees with household exposure(HHE) to VZV (n=24), pre-HHE (n=19, x=13 months post-LAVV) GMTs to all GPs were low in sera from those who subsequently developed lesions (n = 7)[GMTs = 33, 38, 18] and in those who did not (n = 12)[GMTs = 74, 12, 6]. Post-HHE GMTs were higher in those who developed lesions (n = 7)[GMTs = 1413, 1050, 780] compared to those who did not (n = 17)[GMTs = 127, 71, 47], Vaccinees who developed zoster(Z) (n = 5, x = 15 months post-LAVV) had lower pre-Z GMTs [127, 21, 8] than vaccinees who did not (n=30, x=12 months post-LAVV)[GMTs =197, 62,40], Post-Z GMTs showed, boosts for all GPs [GMTs=1940, 1689, 404], Unvaccinated children with ALL & NV who developed Z (n = 12, x = 20 months post-NV) had the following GMTs [269,51, 10] compared to those who did not (n = 30, x = 42 months after NV)[GMTs = 182, 112, 20], Post-Z GMTs showed boosts for all GPs (n=6) [GMTs = 640, 640, 570]. In summary, GMTs to GP-1 > 2 > 3. In vaccinees, at the time of HHE, the height of the antibody titer to the GPs was not helpful in predicting protection from development of breakthrough lesions, but a boost was most evident in those who did develop lesions, probably due to greater viral replication in vesicles. Vaccinees who developed Z had lower GMTs to all GPs, but especially to GP-3, compared to those who did not. Unvaccinated children with ALL & NV who developed Z had lower GMTs to both GP-2 & 3 compared to those who did not.
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LaRussa, P., Gershon, A., Steinberg, S. et al. RESPONSE TO VARICELLA ZOSTER VIRUS (VZV) GLYCOPROTEINS (GPs) IN CHILDREN WITH LEUKEMIA (ALL). Pediatr Res 21 (Suppl 4), 328 (1987). https://doi.org/10.1203/00006450-198704010-00968
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DOI: https://doi.org/10.1203/00006450-198704010-00968