Among the germ cell tumors of the testis, the infantile orchidoblastoma is a separate entity. Histologically it is a pure yolk sac tumor, whereas pure yolk sac tumors are exceptionally rare in adult males. Contrary to testicular germ cell tumors in adults, orchidoblastoma can usually be cured with orchidectomy alone. We speculated that the DNA contents of orchidoblastoma and germ cell tumors of the testis of adult males might be different.
DNA-flow cytometry was performed on suspensions of fresh and paraffin embedded tissue. Histological components in the samples used for DNA measurement were morphologically checked.
Infantile orchidoblastoma (n=9), seminoma (n=17) and non-semi-noma (n=22) showed statistically significant differences in DNA-index (i.e. tumor GI : normal G1 ratio): 1.93, 1.67 and 1.37 respectively. The difference between the DNA-index in orchidoblastoma and germ cell tumors of the adult testis may relate to the absence of spermatogenesis in the former.
Supported by grant GUKC 84-6 from the Netherlands Cancer Foundation and by the Pediatric Oncology Foundation Groningen.
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Oosterhuis, J., de Graaf, S., Meiring, A. et al. 69 DIFFERENCE IN PLOIDY BETWEEN INFANTILE ORCHIDOBLAS‐TOMA AND TESTICULAR GEKM CELL TUMORS OF ADULTS. Pediatr Res 20, 1045 (1986). https://doi.org/10.1203/00006450-198610000-00123