Abstract
Percutaneous absorption at various ages in preterm infants was studied by using a transdermal stable isotope-labelled compound of (13C6) benzoic acid (BA). GC MS was used to analyze hydrolyzed BA recovered from urine at four 6h intervals after application of 1.8mg to 6 infants(31wk gestational age) and 1 infant(25wk gestational age) on d1 and d21 of life. Respectively, mean BArurine creatinine = 10.69 and 18.73 on d1;and 1.33 and 1.47 on d21. The 25wk baby was also evaluated on d2, d7 and d14 and=13.25, 7.14 and 4.27, respectively. A kinetic model was designed to evaluate excretion kinetics in these infants. The cumulative % dose appearing in the urine at time t is given by % = 100 (1 + (k4 exp(-k2t) -k2 exp(-k4t))/(k2-k4), where k2 relates to transport across viable epidermis to blood and k4 characterizes elimination rate of chemical from blood to urine. Agreement between model and infant data is reasonable and the model is a credible approximation of the processes involved. The data indicated that percutaneous absorption was enhanced shortly after birth but gradually declined over 3 weeks to that expected of a full term infant. Further, the developed kinetic model may have value in predicting plasma and urine kinetics in preterm infants.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
West, D., Harvey, D., Halket, J. et al. 2 PERCUTANEOUS ABSORPTION AT VARIOUS AGES IN PRETERM INFANTS. Pediatr Res 20, 1034 (1986). https://doi.org/10.1203/00006450-198610000-00056
Issue Date:
DOI: https://doi.org/10.1203/00006450-198610000-00056