Abstract
It is still uncertain if supplementation of hunan milk with phosphorus(P) alone or with both calciun(Ca) and P better meets mineral requirements of premature infants. We therefore studied the effect of both types of supplementation on biochemical markers of mineral metabolism.
14 prenature infants fed hunan milk(Ca 32mg/dl, P 15, 4mg/dl) were matched to pairs considering birthweight (1430g, 980-1700g;x, range) and gestational age(33weeks, 31-35weeks). In each pair infants were randomly assigned to supplementation with either glucose-l-P(group P;+14mg/dl P) or Ca gluconate plus glucose-l-P(group CaP; +14mg/dl P +27mg/dl Ca). Vitamin D 1000I.U./d were given frcm age 1 week.
Ca and P in serun and in 24h urine, activity of serun alkaline phosphatase(AP), iPTH (midregional antibody) and 250H vitaminD(competitive protein binding assay) were measured when the infants had reached a bodyweight of 1800±75g(day1) and 2150±75g (day 2).
Ca, P, AP, iPTH and 250H vitaminD in serum as well as urinary Ca excretion were within normal range and not significantly different within and between groups on days 1 and 2. Urinary P excretion on day 2 was significantly(p<0,05) lower in group CaP (4, 4±3, 5mg/kg/d) than in group P(19,7±14, 1mg/kg/d) indicating either poorer P absorption or higher P retention in group CaP.
We conclude that supplementation of hman milk with P prevents premature infants from mineral imbalance and impaired bone mineralisation as efficiently as supplementation with both Ca and P.
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Schilling, R., Haschke, F., Schatten, C. et al. MINERAL METAPOLISH IN PREMATURE INFANTS FED HUMAN MILK SUPPLEMENTED WITH PHOSPHORUS OR CALCIUM AND PHOSPHORUS. Pediatr Res 20, 701 (1986). https://doi.org/10.1203/00006450-198607000-00095
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DOI: https://doi.org/10.1203/00006450-198607000-00095