Abstract
Intestinal permeability to substances such as PEG 400/1000, lactulose/rhamnose (LL/RH) and Cr51-EDTA may be changed in patients with eczema, coeliac disease and inflamatory bowel disease. Such changes may reflect an increased uptake of macro-molecular antigens, thereby contributing to the disease process. We have studied the intestinal uptake of two inert sugar molecules (LL/RH) and of the protein bovine serum albumin (BSA). under different experimental conditions. 1) Intestinal anaphylaxis was induced by immunizing adult rats with ovalbumin (OA) and alum. They were then fed 1g BSA (not previously encountered) 1 hour before intra-jejunal challenge. 11) Cetrimide-induced damage: Rats were fed BSA and LL/RH with and without 4mg Cetrimide. Slightly elevated levels of serum BSA and an increased urinary LL/RH ratio were found in the intestinal-anaphylaxis group (p<0.1). No correlation was found between the LL/RH ratios and the BSA levels. In rats with cetrimide-induced gut damage LL/RH excretion ratios were significantly increased (p<0.05) but there was no increase in BSA uptake. Gut permeability to low molecular weight sugars and to macro-molecular protein antgens do not necessarily correlate well but rather is specific to, & dependent upon the underlying pathogenic mechanism
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Boulton, P., Shields, J., Strobel, S. et al. LACK OF CORRELATION BETWEEN CHANGES IN INTESTINAL PERMEABILITY TO INERT SUGAR MOLECULES AND TO PROTEINS DURING (1) HYPERSENSITIVITY REACTIONS AND (11) DETERGENT INDUCED GUT DAMAGE IN THE RAT. Pediatr Res 20, 689 (1986). https://doi.org/10.1203/00006450-198607000-00026
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DOI: https://doi.org/10.1203/00006450-198607000-00026