Abstract
Unhydrolyzed lactose (Lac) is known to reduce normal H2O and Na absorption by the gut. In this study we investigated the effects of Lac without or with added glucose (Glu) on the jejunal absorption of H2O, Na and K in itial-(M) and well-(C) nourished rats. Protein-energy malnutrition (PEM) was induced in juvenile rats by feedings of 4% protein and reduced carbohydrate. C rats received a complete diet. Absorption was studied by one-pass perfusions of 20-30 cm segments with sols, containing 60 mM Lac (I) or 60 mM Lac + 50 mM Glu (II). Both sols. included (in mEq/1) : 30 Na, 20 K and 30 HCO3 · Phenol red and 3H2O were used as markers. The net H2O flux (NWF) was the same in M and c rats with I (C= 1.81±0.09; M= 1.87±0.10 μl/min x cm), but when Glu was present (II) the improvement of NWF was greater in M rats (C= 2.52μ0.11; M= 5.66μ0.23, P<0.001). This effect of Glu was mostly due to a greatly diminished efflux (C= 4.85μ0.26; M= 0.18μ0.24, P<0.001) in rats with PEM. Na transport was changed from secretion to absorption by Glu in M rats (C= 2.9μ14.8; M= 285.0μ13.7 nEq/min x cm, P<0.001), while Lac only produced secretion in both groups (C= -5.9±0.9; M= -28.0±8.3). K absorption was greater in M rats regardless of the presence of Glu. The data suggest that in PEM a more significant inprovement over the negative effects of unhydrolyzed Lac on H2O and electrolyte transport can be achieved by the addition of a moderate amount of Glu to a feeding formula.
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Wapnir, R., Beckman, J., Lifshitz, F. et al. 750 WATER AND ELECTROLYTE ABSORPTION IN MALNUTRITION EFFECT OF LACTOSE AND REVERSAL BY GLUCOSE. Pediatr Res 19, 235 (1985). https://doi.org/10.1203/00006450-198504000-00780
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DOI: https://doi.org/10.1203/00006450-198504000-00780