Abstract
To assess whether pulsatile GH secretion changes during pubertal development, 23 intact and 21 castrate male macaques (rhesus and cynomologous) from prepubertal through adult life were evaluated. Blood was withdrawn at 15 min intervals for 12 or 24 hr through a femoral venous catheter. All animals were fit with a mobile vest and tether assembly. Pubertal development was assessed on the basis of chronological age, gonadotropin and testosterone secretion, testicular volume, hCG challenge tests and skeletal age. The pulsatile secretory GH data are summarized below:
These data suggest that pulsatile GH secretion does not change significantly during pubertal development in male monkeys and that endogenous testosterone does not alter pulsatile GH secretion.
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Spiliotis, B., Root, A., Hu, CS. et al. 496 PULSATILE GROWTH HORMONE (GH) SECRETION DURING PUBERTAL DEVELOPMENT IN INTACT AND CASTRATE MONKEYS. Pediatr Res 19, 193 (1985). https://doi.org/10.1203/00006450-198504000-00526
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DOI: https://doi.org/10.1203/00006450-198504000-00526