Abstract
Pregnant Holtzman rats were studied at 19 and 20 days gestation. Animals were anesthetized at -30 min with pentobarbitol 60 mg/kg IP. 5 ug HPGRH 1–44 or normal saline was administered IV at 0 min. Blood for maternal GH measurement was obtained via cardiac puncture at 0 min and following decapitation at 11 min. Fetuses were removed by C-section between 7 and 11 min and cardiac blood from littermates pooled for a single fetal GH determination. *x±SD **ng/ml
Mean maternal GH levels rose significantly (p < 0.005) in animals receiving HPGRH and were unchanged in those receiving saline. Mean fetal GH levels were significantly greater (p < 0.005) at 20 vs 19 days gestation. There were no significant differences between mean fetal GH concentrations of mothers receiving HPGRH and those receiving saline. HPGRH increases GH concentrations in the pregnant rat. HPGRH administration to the pregnant rat during late gestation does not increase GH concentrations in the fetus suggesting either that HPGRH does not cross the rat placenta or that the fetal rat pituitary is insensitive to HPGRH at this dosage.
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Shulman, D., Duckett, G., Sweetland, M. et al. 493 EFFECTS OF HUMAN PANCREATIC GROWTH HORMONE RELEASING HORMONE (HPGRH) ON GROWTH HORMONE (GH) SECRETION IN PREGNANT AND FETAL RATS. Pediatr Res 19, 193 (1985). https://doi.org/10.1203/00006450-198504000-00523
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DOI: https://doi.org/10.1203/00006450-198504000-00523