Abstract
Long-acting LHRH analogues are known to be effective in the suppression of precocious puberty. We used native LHRH administered subcutaneously via a portable infusion pump in an 18-month old male infant with precocious puberty secondary to a hypothalamic tumor. The hormonal data in relation to the therapeutic management is summarized in the table below.
The paradoxical rise in testosterone after almost full suppression can be explained on the basis of needle dislodgement because of the increased activity in this patient's age group. From our experience, we conclude and recommend that if LHRH analogues are not available to suppress puberty then native LHRH might be given provided it can be administered continuously.
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Noto, R., Rosati, M., Lala, V. et al. 477 USE OF NATIVE LHRH IN THE TREATMENT OF PRECOCIOUS PUBERTY. Pediatr Res 19, 190 (1985). https://doi.org/10.1203/00006450-198504000-00507
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DOI: https://doi.org/10.1203/00006450-198504000-00507